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E028 Splash

Neocate E028 Splash

The first and only hypoallergenic amino acid-based ready-to-drink medical food for children over the age of one

This formulation is available in the US and Canada.

Main Features:
  • Hypoallergenic
  • 100% free amino acids
  • To supplement essential nutrients in children on elimination diets
  • Gluten and casein-free
  • Convenient ready to feed 8 fl oz Tetra Pak®
  • Available in three great flavors:
    Tropical Fruit
  • Standard dilution = 1 kcal/mL
  • Osmolality = 820 mOsm/kg
  • Energy distribution:
    Protein 10%
    Carbohydrate 58%
    Fat (MCT 35% / LCT 65 %) 32%


  • Gastrointestinal tract impairment
  • Cow and soy milk allergy
  • Multiple food protein intolerance
  • Eosinophilic esophagitis
  • Gastroesophageal reflux
  • Short bowel syndrome
  • Other medical conditions for which an amino acid-based diet is required


Directions for Preparation and Use:

  • Intake to be determined by a medical professional and is dependent on the age, body weight, and medical condition of the patient. EO28 Splash may be administered as a tube feed. Shake well before use. If taken orally, best served chilled.
  • Do not use a microwave oven to warm formula.


  • Store unopened product in a cool dry place. Once opened, E028 Splash should be stored in a refrigerator and kept no longer than 24 hours. Do not freeze EO28 Splash.
Ordering Information:
Product Code
Reimbursement Code
Calories Per Box
12670 - Grape
27 x 237 mL
12666 - Tropical Fruit
27 x 237 mL
11050 - Orange-Pineapple
27 x 237 mL

Click here to order Neocate E028 Splash.

Clinical References (Selected List)

  1. Andorsky DJ, Lund DP, Lillehei CW, Jaksic T, Dicanzio J, Richardson DS, et al. Nutritional and other postoperative management of neonates with short bowel syndrome correlates with clinical outcomes. J Pediatr. 2001;139(1):27-33.
  2. Markowitz JE, Spergel JM, Ruchelli E, Liacouras CA. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol. 2003;98(4):777-782.
  3. Hill, DJ, Cameron, DJS., Francis, DEM, et al. Challenge confirmation of late onset reactions to extensively hydrolyzed formulas in infants with multiple food protein intolerance. J Allergy Clin Immun. 1995;96:386-394.
  4. de Boissieu D, Dupont C. Time course of allergy to extensively hydrolyzed cow's milk proteins in infants. J Pediatr. 2000;136:119-120.
  5. Sampson HA, James JM, Bernhisel-Broadbent J. Safety of an amino acid derived infant formula in children allergic to cow milk. Pediatrics. 1992;90(3):463-465.
  6. Niggemann B, Binder C, Dupont C, Hadji S, Arvola T, Isolauri E. Prospective controlled multicentre study on the effect of an amino acid based formula in infants with cow's milk allergy/intolerance and atopic dermatitis. Pediatr Allergy Immu. 2001;12:78-82.
  7. Isolauri E, Sampson HA. Use of an amino acid-based formula in the management of cow's milk allergy and multiple food protein intolerance in children. J Allergy Clin Immun. 2004;113:S154.
  8. Kelly K, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA. Eosinophilic esophagitis attributed to gastroesophageal reflux: Improvement with an amino-acid-based formula. Gastroenterology. 1995;109:1503-1512.
  9. Miele E, Staiano A, Tozzi A, Auricchio R, Paparo F, Troncone R. Clinical response to amino acid-based formula in neurologically impaired children with refractory esophagitis. J Pediatr Gastr Nutr. 2002;35(3):314-319.
  10. Rudolph CD, Mazur LJ, Liptak GS, Baker RD, Boyle JT, Colletti RB, et al. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastr Nutr. 2001;32(2).92.
  11. Bines J, Francis D, Hill D. Reducing parenteral requirement in children with short bowel syndrome: impact of an amino acid-based complete infant formula. J Pediatr Gastr Nutr. 1998;26(2):123-128.






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