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Periflex Advance

Periflex Advance

A phenylalanine-free, powdered medical food for the dietary management of phenylketonuria (PKU) in older children and adults, including pregnant women and women of child-bearing age.

Click here to order Periflex Advance.

This formulation is available in the US and Canada.

Main Features:
  • Phenylalanine-free
  • Easy transition from Periflex Junior
  • Contains a balanced mixture of all other essential and non-essential amino acids, carbohydrate, fat, vitamins, minerals and trace elements
  • Excellent balance of linoleic acid and α-linolenic acid, providing a preferable 4:1 ratio of n-6 to n-3
  • Age-appropriate DRI formulation
  • Periflex Advance provides 35 g of protein equivalent and 12.6 g of fat per 100 g of powder
  • Meets protein requirements in lower volume
  • Pleasant taste, smell and texture
  • Available in unflavored and orange
  • Optimal nutrition of all ages
  • Osmolality (mOsm/kg)

    1 to 5



    1 to 4




  • Phenylketonuria

Directions for Preparation and Use:

Use only under the direction of a physician or dietitian. Periflex Advance must be consumed in conjunction with natural protein, fluid and other nutrients in quantities prescribed by a physician or dietitian to meet phenylalanine and general nutritional requirements.

Periflex Advance is intended for older children and adults, including pregnant women and women of child-bearing age.

Intake of Periflex Advance is dependent on the age, bodyweight and medical condition of the individual. Periflex Advance should be divided into equal portions and distributed throughout the day.

Mixing Instructions:

  • Add the desired volume of water to a shaker or other container with a tight fitting lid. Then add the prescribed amount of powder and shake until fully blended together. Dilution guidelines are shown in the table below. Periflex Advance is best served chilled.
  • Periflex Advance tastes great when blended with 1 fl oz (30 mL) of water for every 5 to 6 grams of powder.
Dilution Guidelines   Household Measurements

Volume of Water

Prescribed Amount Approx. Protein Equivalent

2 to 3 fl oz (60-90 mL)

16 g (2 Tbsp)

6 g

4 to 5 fl oz (120-150 mL)

32 g (1/4 cup)

11 g

8 to 10 fl oz (240-300 mL)

64 g (1/2 cup)

22 g

16 to 20 fl oz (480-600 mL)

128 g (1 cup)

45 g

Household Measurement g Product g Protein
1 Tablespoon 8 2.8
1/4 Cup 32 11
1/2 Cup 64 22
1 Cup 128 45
For accuracy, the powder should be weighed on a gram scale.
  • Once prepared, store formula in a refrigerator for no longer than 24 hours from the time of preparation. Shake or stir prepared formula immediately before use.
  • Dilutions are guidelines only. Periflex Advance may be consumed in a more concentrated form (e.g., a paste or concentrated drink) by using less water. If consumed in a concentrated form, water or other drinks should also be taken at the same time.
  • Must only be consumed by individuals with proven phenylketonuria while under strict medical supervision.
  • Not intended for infants.
  • Not suitable as a sole source of nutrition.
  • Not for parenteral use.
  • Store unopened can at room temperature. Do not store at extreme temperatures. Once opened, reseal can and store in a cool, dry place (not in refrigerator) and use within one month.

Ordering Information:

Product Code Reimbursement Code Packaging
118305 (Unflavored) 49735-0183-05

6 x 454 g (1 lb)

118307 (Orange) 49735-0183-07

6 x 454 g (1 lb)






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